Compared to single-unit dosage forms, oral multi particulate drug-delivery systems (e.g. pellets, granules) offer biopharmaceutical advantages in terms of a more even and predictable distribution and transportation in the gastrointestinal tract. Today pelletization technology represents an efficient pathway for manufacture of drug delivery system. There is different pelletization and granulation techniques available to prepare drug loaded spherical particles or granules. Extrusion-spheronization seems to be the most promising process for the optimum delivery of many potent drugs having high systemic toxicity. It also offers immense pharmaceutical applicability due to the benefits of high loading capacity of active ingredient(s), narrow size distribution, and cost-effectiveness. On application of a specific coat, these systems can also aid in site-specific delivery, thereby enhancing the bioavailability of many drugs. In this review article we mainly focus on the process of Extrusion-spheronization and machine (friction plate pattern, speed, retention time, charge volume) product (excipients, API level, moisture, binders, and lubricants) parameters. Here we also discussed about Holt Melt Extrusion (HME) process, parameters and it�s applications in the pharmaceutical industry.
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